Abstract: In this paper, we propose a new method based on the combination of the ant algorithm and local search algorithm 2-OPT to find shortage path in wireless networks. According to the results of combined algorithms, it significantly optimizes the algorithm for finding the shortest route. While there are a few researches about wireless network routing by the ant algorithm in literature, this research mainly deals with finding optimized routing in big wireless networks by using ant algorithm and local search algorithm 2-OPT. Based on the obtained results of the proposed algorithm, the route is shorter and more precise than the route resulted from ant colony, particle swarm optimization and genetic algorithm in a big wireless network.