Abstract: Epidemiology research, particularly in sport is one of the essential tools to identify injuries and strategies for the prevention of sports injuries can be designed and formulated by specifying them. The present study is practical in terms of objective and it is descriptive-field and retrospective in terms of data collection. The statistical population of this research consists of all male athletes in handball, basketball and football in Khuzestan province. The statistical sample consists of 36 handball players, 40 football players and 32 basketball players. Data analysis was done using one-way analysis of variance and multiple regression using SPSS version 18. The result of one-way analysis of variance showed that a significant difference exists among the total injuries to lower extremities (F = 172.2; p= 0.00), knee (F = 10.6; P = 0.00), ankle (F = 9.4; P = 0.00) in the three groups. Tukey post hoc test results revealed that in all three cases, handball injuries were most prevalent, followed by basketball, and football.