Abstract: The main objective of this study was to evaluate the impact of mobile phone short messages system on physical activity and anthropometric measures among postmenopausal women in Iran. This was a randomized controlled trial in which 100 postmenopausal women with body mass index (BMI) ≥25were recruited randomly in Ahvaz, Iran. Weight, height, waist circumference, hip circumference, waist-hip ratio and physical activity were measured at the beginning and four months after intervention. Intervention was including; 49 short messages with the content of motivating the subjects to enhance their daily physical activity that sent for participants every other day. The control group received the routine care. The descriptive, independent t-test, paired t-test and chi-square test were utilized for statistical purposes. At the end of the study, weight reduced significantly in the control group compared to the intervention group (p=0.004) and physical activity level was reduced in both groups after four months; however the reduction was more evident in the control group. There was not any significant difference between two groups regarding weight, BMI, waist circumference, hip circumference, waist-hip ratio and physical activity. Further studies with aim of compare mobile short messages with other educational methods are recommended.