Abstract: This study aimed to explore the effect of computer-assisted Language Learning (CALL) on the reading comprehension of expository texts of Iranian female senior. The study was designed as a true-experimental research-Randomized Control Experimental Group, Pre-test-Post-test Design. The subjects in this study were 60 female senior from Islamic Azad University of Khodabandeh who are studying English as their major course. They were senior who had been selected out of many other EFL students through the Standardized Nelson Test. These subjects were divided into two groups, control group and experimental group.The experimental group was taught using computer-assisted instructions in a language laboratory, while subjects in the control group were taught using a traditional method of instructions in traditional classroom setting. The training took 12 sessions and the same instructor taught the groups three hours each session. During the first week, a pre-test was given to both groups. Then, a post-test was given at the end of the instructions. An independent sample t-test appeared to be an appropriate tool for data analysis in this study since there were two groups who were evaluated twice through pre and posttest. The results showed that there were statistically significant differences between two groups that can be attributed to the effect of CALL on the reading comprehension of expository texts.