Abstract: The present study aimed to extend our knowledge by exploring predictive role of self-efficacy and autonomy in Medical learners’ (EMP) language performances.Gender was another variable of interest in the study. Set out to explore, self-efficacy and autonomy scales besides English achievement test were administrated and analyzed. Results of statisticalanalysis of Pearson correlation denote that there is a strong relationship between students' self-efficacy beliefs and their language performances (r=.893). In fact, it demonstrates the contributing effect of efficacy beliefs in taking responsibility in learning which lead to learners’ significant attainments in learning tasks.Statistical analysis of the data also revealed that there is a significant correlation between learners' autonomous beliefs and their general English performance(r=.845). It is implied that faith in capabilities and directing and controlling learning are necessities to enhance EMP learners’ achievements.Furthermore, the results show no significant differences between learners' autonomy with regard to their gender(t=.43). The study has some pedagogical implications which will be discussed in the paper.